What is the mutation news in England? I explain it not with sensations or headlines, but with the scientific data we have:
What is Newly mutated COVID19 virus? What’s so different that it raised global alarm?
Newly mutated COVID19 virus has interesting mutation on B.1.1.7 Lineage Cluster mutation, which reported by CovidGenomicsUK.
What is this B.1.1.7 lineage set? We can look at the genome sequences of all living things with a “phylogenetic” family tree. We can compare the genome sequences of viruses in the family tree and see genetic diversity and new branching. These branches are given names, such as B.1.1.7 (see image)
What mutations are in this B.1.1.7 lineage set? There is a lot, see image. There are hundreds of SARSCOV2 lineages and mutations occur in each branch, this is very normal. There can be mutations in every reproductive cycle of the virus. Spike sheath protein mutations concern us the most.
For example, the N501Y mutation (ie the mutation from Asparagine to Tyrosine at the 501th position of the Spike protein) was previously able to adapt to the mouse ACE2 receptor by passing from mouse to mouse in mouse experiments. See:
https://science.sciencemag.org/content/369/6511/1603.full
In lab experiments, we know that the N501Y mutation can bind to the ACE2 receptor better. Reason: Virus Spike protein is one of the 6 important contact amino acids at the point where it attaches to ACE2. See image and source:
https://science.sciencemag.org/content/367/6485/1444.full
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Blog| Mehdi Gorbani 